View source for 4pxj


==Crystallographic structure of the LZII fragment (anti-parallel orientation) from JIP3==
<StructureSection load='4pxj' size='340' side='right'caption='[[4pxj]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4pxj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PXJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pxj OCA], [https://pdbe.org/4pxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pxj RCSB], [https://www.ebi.ac.uk/pdbsum/4pxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pxj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/JIP3_HUMAN JIP3_HUMAN] The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Llinas P]]
[[Category: Menetrey J]]