View source for 4qc9


==Crystal structure of Vaccinia virus uracil-DNA glycosylase mutant 3GD4==
<StructureSection load='4qc9' size='340' side='right'caption='[[4qc9]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qc9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Ankara Vaccinia virus Ankara]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QC9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.259&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qc9 OCA], [https://pdbe.org/4qc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qc9 RCSB], [https://www.ebi.ac.uk/pdbsum/4qc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qc9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UNG_VACCW UNG_VACCW] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA (By similarity).

==See Also==
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus Ankara]]
[[Category: Banerjee S]]
[[Category: Chattopadhyay D]]
[[Category: Nash T]]
[[Category: Nuth M]]
[[Category: Ricciardi R]]
[[Category: Sartmatova D]]
[[Category: Schormann N]]