View source for 4qgn


==Human acireductone dioxygenase with iron ion and L-methionine in active center==
<StructureSection load='4qgn' size='340' side='right'caption='[[4qgn]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qgn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QGN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qgn OCA], [https://pdbe.org/4qgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qgn RCSB], [https://www.ebi.ac.uk/pdbsum/4qgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qgn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTND_HUMAN MTND_HUMAN] Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.[HAMAP-Rule:MF_03154]<ref>PMID:11602742</ref> <ref>PMID:15938715</ref> 

==See Also==
*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Borowski T]]
[[Category: Chruszcz M]]
[[Category: Milaczewska AM]]
[[Category: Minor W]]
[[Category: Niedzialkowska E]]
[[Category: Petkowski JJ]]