View source for 4qob


==Crystal structure of cPOP1==
<StructureSection load='4qob' size='340' side='right'caption='[[4qob]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qob]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QOB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qob OCA], [https://pdbe.org/4qob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qob RCSB], [https://www.ebi.ac.uk/pdbsum/4qob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qob ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYDC1_HUMAN PYDC1_HUMAN] Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.<ref>PMID:12656673</ref> <ref>PMID:24871464</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Park HH]]