View source for 4qox


==Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500==
<StructureSection load='4qox' size='340' side='right'caption='[[4qox]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QOX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.748&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXR:3-(3-BROMOBENZYL)-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>DXR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qox OCA], [https://pdbe.org/4qox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qox RCSB], [https://www.ebi.ac.uk/pdbsum/4qox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qox ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDPK4_PLAF7 CDPK4_PLAF7] Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).

==See Also==
*[[Calcium-dependent protein kinase|Calcium-dependent protein kinase]]
*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Amani M]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: He H]]
[[Category: Hui R]]
[[Category: Hutchinson A]]
[[Category: Lin YH]]
[[Category: Loppnau P]]
[[Category: Lovato DV]]
[[Category: Neculai M]]
[[Category: Ravichandran M]]
[[Category: Seitova A]]
[[Category: Walker JR]]
[[Category: Wernimont AK]]