View source for 4qpf


==New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption==
<StructureSection load='4qpf' size='340' side='right'caption='[[4qpf]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QPF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=39L:[1-FLUORO-2-(IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>39L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpf OCA], [https://pdbe.org/4qpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qpf RCSB], [https://www.ebi.ac.uk/pdbsum/4qpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

==See Also==
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barnett BL]]
[[Category: Duan Z]]
[[Category: Dunford JE]]
[[Category: Ebetino FH]]
[[Category: Jeans G]]
[[Category: Kwaasi AA]]
[[Category: Lundy M]]
[[Category: Mazur A]]
[[Category: Russell RGG]]
[[Category: Triffitt J]]