View source for 4qpg


==Crystal structure of empty hepatitis A virus==
<StructureSection load='4qpg' size='340' side='right'caption='[[4qpg]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qpg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_hepatitis_A_virus Human hepatitis A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QPG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpg OCA], [https://pdbe.org/4qpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qpg RCSB], [https://www.ebi.ac.uk/pdbsum/4qpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8QXR6_9PICO Q8QXR6_9PICO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Hepatitis A virus (HAV) remains enigmatic, despite 1.4 million cases worldwide annually. It differs radically from other picornaviruses, existing in an enveloped form and being unusually stable, both genetically and physically, but has proved difficult to study. Here we report high-resolution X-ray structures for the mature virus and the empty particle. The structures of the two particles are indistinguishable, apart from some disorder on the inside of the empty particle. The full virus contains the small viral protein VP4, whereas the empty particle harbours only the uncleaved precursor, VP0. The smooth particle surface is devoid of depressions that might correspond to receptor-binding sites. Peptide scanning data extend the previously reported VP3 antigenic site, while structure-based predictions suggest further epitopes. HAV contains no pocket factor and can withstand remarkably high temperature and low pH, and empty particles are even more robust than full particles. The virus probably uncoats via a novel mechanism, being assembled differently to other picornaviruses. It utilizes a VP2 'domain swap' characteristic of insect picorna-like viruses, and structure-based phylogenetic analysis places HAV between typical picornaviruses and the insect viruses. The enigmatic properties of HAV may reflect its position as a link between 'modern' picornaviruses and the more 'primitive' precursor insect viruses; for instance, HAV retains the ability to move from cell-to-cell by transcytosis.

Hepatitis A virus and the origins of picornaviruses.,Wang X, Ren J, Gao Q, Hu Z, Sun Y, Li X, Rowlands DJ, Yin W, Wang J, Stuart DI, Rao Z, Fry EE Nature. 2014 Oct 19. doi: 10.1038/nature13806. PMID:25327248<ref>PMID:25327248</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4qpg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human hepatitis A virus]]
[[Category: Large Structures]]
[[Category: Fry EE]]
[[Category: Gao Q]]
[[Category: Hu Z]]
[[Category: Li X]]
[[Category: Rao Z]]
[[Category: Ren J]]
[[Category: Rowlands DJ]]
[[Category: Stuart DI]]
[[Category: Sun Y]]
[[Category: Wang J]]
[[Category: Wang X]]
[[Category: Yin W]]