View source for 4rau


==crystal structure of RTOFab in complex with human PF4==
<StructureSection load='4rau' size='340' side='right'caption='[[4rau]], [[Resolution|resolution]] 3.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4rau]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RAU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.74&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rau OCA], [https://pdbe.org/4rau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rau RCSB], [https://www.ebi.ac.uk/pdbsum/4rau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rau ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLF4_HUMAN PLF4_HUMAN] Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.<ref>PMID:7644496</ref> 

==See Also==
*[[C-X-C motif chemokine 3D structures|C-X-C motif chemokine 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Cai Z]]
[[Category: Greene MI]]
[[Category: Liu Q]]
[[Category: Zhu Z]]