View source for 4re8


==Crystal Structure of TR3 LBD in complex with Molecule 5==
<StructureSection load='4re8' size='340' side='right'caption='[[4re8]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4re8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RE8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3MJ:1-(3,4,5-TRIHYDROXYPHENYL)DODECAN-1-ONE'>3MJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4re8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4re8 OCA], [https://pdbe.org/4re8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4re8 RCSB], [https://www.ebi.ac.uk/pdbsum/4re8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4re8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cai QX]]
[[Category: Hou PP]]
[[Category: Li AZ]]
[[Category: Li FW]]
[[Category: Lin TW]]
[[Category: Tian XY]]
[[Category: Weijia W]]
[[Category: Wu Q]]
[[Category: Yuan W]]