View source for 4rg7


==Crystal structure of APC3==
<StructureSection load='4rg7' size='340' side='right'caption='[[4rg7]], [[Resolution|resolution]] 4.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4rg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RG7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg7 OCA], [https://pdbe.org/4rg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rg7 RCSB], [https://www.ebi.ac.uk/pdbsum/4rg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDC27_HUMAN CDC27_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Miller DJ]]
[[Category: Schulman BA]]
[[Category: Yamaguchi M]]
[[Category: Yu S]]