View source for 4rhy


==Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease==
<StructureSection load='4rhy' size='340' side='right'caption='[[4rhy]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4rhy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RHY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3196&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3QG:[2-({2-[BIS(2-PHOSPHONOETHYL)AMINO]ETHYL}[2-(6-OXO-3,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]AMINO)ETHYL]PHOSPHONIC+ACID'>3QG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhy OCA], [https://pdbe.org/4rhy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhy RCSB], [https://www.ebi.ac.uk/pdbsum/4rhy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HGPRT_MYCTU HGPRT_MYCTU] Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi (PubMed:19362594, PubMed:25915781). Thus, specifically recycles hypoxanthine and guanine imported from the external medium, and converts them to IMP and GMP, respectively. Cannot use xanthine as substrate (PubMed:19362594).<ref>PMID:19362594</ref> <ref>PMID:25915781</ref> 

==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Ra]]
[[Category: Eng WS]]
[[Category: Guddat LW]]
[[Category: Hockova D]]
[[Category: Keough DT]]
[[Category: Naesens LMJ]]
[[Category: Spacek P]]
[[Category: West NP]]
[[Category: Woods K]]