View source for 4rl0


==Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins==
<StructureSection load='4rl0' size='340' side='right'caption='[[4rl0]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4rl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RL0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3S0:(2R,5S)-5-[(CARBAMOYLOXY)METHYL]-2-[(R)-CARBOXY{[(2Z)-2-(FURAN-2-YL)-2-(METHOXYIMINO)ACETYL]AMINO}METHYL]-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>3S0</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rl0 OCA], [https://pdbe.org/4rl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rl0 RCSB], [https://www.ebi.ac.uk/pdbsum/4rl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rl0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.

==See Also==
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
</StructureSection>
[[Category: Klebsiella pneumoniae]]
[[Category: Large Structures]]
[[Category: Ding J]]
[[Category: Feng H]]
[[Category: Liu W]]
[[Category: Liu X]]
[[Category: Wang D-C]]
[[Category: Xu X]]
[[Category: Zang S]]
[[Category: Zhang Y]]
[[Category: Zhu D]]