View source for 4ruh


==Crystal structure of Human Carnosinase-2 (CN2) in complex with inhibitor, Bestatin at 2.25 A==
<StructureSection load='4ruh' size='340' side='right'caption='[[4ruh]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ruh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BES:2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC+ACID'>BES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ruh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ruh OCA], [https://pdbe.org/4ruh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ruh RCSB], [https://www.ebi.ac.uk/pdbsum/4ruh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ruh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CNDP2_HUMAN CNDP2_HUMAN] Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.<ref>PMID:17121880</ref> <ref>PMID:19346245</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kaushik A]]
[[Category: Kumaran S]]
[[Category: Singh AK]]
[[Category: Singh RP]]
[[Category: Pandya V]]