View source for 4rzg


==Crystal Structure Analysis of the DNPA-bounded NUR77 Ligand binding Domain==
<StructureSection load='4rzg' size='340' side='right'caption='[[4rzg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4rzg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RZG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZHN:PENTYL+(3,5-DIHYDROXY-2-NONANOYLPHENYL)ACETATE'>ZHN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rzg OCA], [https://pdbe.org/4rzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rzg RCSB], [https://www.ebi.ac.uk/pdbsum/4rzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rzg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen H]]
[[Category: Li A]]
[[Category: Li F]]
[[Category: Li L]]
[[Category: Lin T]]
[[Category: Liu Y]]
[[Category: Tian X]]
[[Category: Wu Q]]