View source for 4twm


==Crystal structure of dioscorin from Dioscorea japonica==
<StructureSection load='4twm' size='340' side='right'caption='[[4twm]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4twm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioscorea_japonica Dioscorea japonica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twm OCA], [https://pdbe.org/4twm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twm RCSB], [https://www.ebi.ac.uk/pdbsum/4twm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DIOA3_DIOJA DIOA3_DIOJA] Storage protein of tuber. Involved in protection against oxidative stress (Probable). Has carbonate dehydratase, trypsin inhibitor, dehydroascorbate (DHA) reductase and monodehydroascorbate (MDA) reductase activities (PubMed:22195572). Catalyzes the reactions of carbonate dehydratase and DHA reductase independently of zinc and glutathione (GSH). The coupled reaction is capable of recycling a plant antioxidant ascorbate using ubiquitous compounds H(2)O and CO(2) (PubMed:25747844). Exhibits antioxidant activity. Able to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. Exhibits immunomodulatory activity. Activates Toll-like receptor 4 signaling pathways by up-regulating the gene expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1 beta and interleukin-6, and chemokines RANTES and MCP-1, in mouse RAW 264.7 macrophages. Stimulates the phagocytosis of E.coli by the LPS-treated mouse macrophages (PubMed:22796748).<ref>PMID:22195572</ref> <ref>PMID:22796748</ref> <ref>PMID:25747844</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dioscorea japonica]]
[[Category: Large Structures]]
[[Category: Miyakawa T]]
[[Category: Nakamura A]]
[[Category: Tanokura M]]
[[Category: Xue YL]]