View source for 4u42


==MAP4K4 T181E Mutant Bound to inhibitor compound 1==
<StructureSection load='4u42' size='340' side='right'caption='[[4u42]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4u42]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U42 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3C8:6-[(3S)-3-(4-METHYL-1H-PYRAZOL-3-YL)PIPERIDIN-1-YL]PYRIDO[3,2-D]PYRIMIDIN-4-AMINE'>3C8</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u42 OCA], [https://pdbe.org/4u42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u42 RCSB], [https://www.ebi.ac.uk/pdbsum/4u42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u42 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Coons M]]
[[Category: Harris SF]]
[[Category: Wu P]]