View source for 4uco


==Fragment bound to H.influenza NAD dependent DNA ligase==
<StructureSection load='4uco' size='340' side='right'caption='[[4uco]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UCO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D41:7-AMINO-2-TERT-BUTYL-4-(1H-PYRROL-2-YL)PYRIDO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>D41</scene>, <scene name='pdbligand=IWH:1-(2,4-DIMETHYLBENZYL)-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>IWH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uco OCA], [https://pdbe.org/4uco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uco RCSB], [https://www.ebi.ac.uk/pdbsum/4uco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uco ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNLJ_HAEIN DNLJ_HAEIN] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).

==See Also==
*[[DNA ligase 3D structures|DNA ligase 3D structures]]
__TOC__
</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Large Structures]]
[[Category: Boriack-Sjodin PA]]
[[Category: Brassington C]]
[[Category: Carcanague D]]
[[Category: Embrey K]]
[[Category: Eyermann CJ]]
[[Category: Giacobbe RA]]
[[Category: Gingipali L]]
[[Category: Gowravaram M]]
[[Category: Hale M]]
[[Category: Harang J]]
[[Category: Howard T]]
[[Category: Ioannidis G]]
[[Category: Jahic H]]
[[Category: Kutschke A]]
[[Category: Laganas VA]]
[[Category: Loch J]]
[[Category: Miller MD]]
[[Category: Murphy-Benenato KE]]
[[Category: Oguto H]]
[[Category: Otterbein L]]
[[Category: Patel SJ]]
[[Category: Shapiro AB]]