View source for 4udq


==Crystal structure of 5-hydroxymethylfurfural oxidase (HMFO) in the reduced state==
<StructureSection load='4udq' size='340' side='right'caption='[[4udq]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4udq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylovorus_sp._MP688 Methylovorus sp. MP688]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UDQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4udq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4udq OCA], [https://pdbe.org/4udq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4udq RCSB], [https://www.ebi.ac.uk/pdbsum/4udq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4udq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HMFO_METS6 HMFO_METS6] Involved in the degradation and detoxification of 5-(hydroxymethyl)furfural (HMF) by mediating its oxidation to furan-2,5-dicarboxylate (FDCA), a biobased platform chemical for the production of polymers. Active with a wide range of aromatic and aliphatic primary alcohols and aldehydes: acts on alcohol groups and requires the spontaneous hydration of aldehyde groups for their oxidation (PubMed:24271187, PubMed:24802551). To a lesser extent, is also able to catalyze the oxidation of thiols that are structurally similar to its alcohol substrates, yielding the corresponding thiocarbonyls (PubMed:25284255).<ref>PMID:24271187</ref> <ref>PMID:24802551</ref> <ref>PMID:25284255</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Methylovorus sp. MP688]]
[[Category: Binda C]]
[[Category: Dijkman W]]
[[Category: Fraaije M]]
[[Category: Mattevi A]]