View source for 4uer


==40S-eIF1-eIF1A-eIF3-eIF3j translation initiation complex from Lachancea kluyveri==
<SX load='4uer' size='340' side='right' viewer='molstar' caption='[[4uer]], [[Resolution|resolution]] 6.47&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uer]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Lachancea_kluyveri Lachancea kluyveri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UER FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.47&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uer OCA], [https://pdbe.org/4uer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uer RCSB], [https://www.ebi.ac.uk/pdbsum/4uer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uer ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0J9X202_LACKL A0A0J9X202_LACKL] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.[ARBA:ARBA00025502][RuleBase:RU004365]
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== Publication Abstract from PubMed ==
Eukaryotic translation initiation requires cooperative assembly of a large protein complex at the 40S ribosomal subunit. We have resolved a budding yeast initiation complex by cryo-EM, allowing placement of prior structures of eIF1, eIF1A, eIF3a, eIF3b and eIF3c. Our structure highlights differences in initiation-complex binding to the ribosome compared to that of mammalian eIF3, demonstrates a direct contact between eIF3j and eIF1A and reveals the network of interactions between eIF3 subunits.

Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex.,Aylett CH, Boehringer D, Erzberger JP, Schaefer T, Ban N Nat Struct Mol Biol. 2015 Mar;22(3):269-71. doi: 10.1038/nsmb.2963. Epub 2015 Feb, 9. PMID:25664723<ref>PMID:25664723</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 4uer" style="background-color:#fffaf0;"></div>

==See Also==
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
<references/>
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[[Category: Lachancea kluyveri]]
[[Category: Large Structures]]
[[Category: Aylett CHS]]
[[Category: Ban N]]
[[Category: Boehringer D]]
[[Category: Erzberger JP]]
[[Category: Schaefer T]]