View source for 4ur4


==Structure of the type III fish antifreeze protein from Zoarces viviparus ZvAFP13==
<StructureSection load='4ur4' size='340' side='right'caption='[[4ur4]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ur4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zoarces_viviparus Zoarces viviparus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UR4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ur4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ur4 OCA], [https://pdbe.org/4ur4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ur4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ur4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ur4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A3EYI7_ZOAVI A3EYI7_ZOAVI] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Antifreeze proteins (AFPs) are essential components of many organisms adaptation to cold temperatures. Fish type III AFPs are divided into two groups, SP isoforms being much less active than QAE1 isoforms. Two type III AFPs from Zoarces viviparus, a QAE1 (ZvAFP13) and an SP (ZvAFP6) isoform, are here characterized and their crystal structures determined. We conclude that the higher activity of the QAE1 isoforms cannot be attributed to single residues, but rather a combination of structural effects. Furthermore both ZvAFP6 and ZvAFP13 crystal structures have water molecules around T18 equivalent to the tetrahedral-like waters previously identified in a neutron crystal structure. Interestingly, ZvAFP6 forms dimers in the crystal, with a significant dimer interface. The presence of ZvAFP6 dimers was confirmed in solution by native electrophoresis and gel filtration. To our knowledge this is the first report of dimerization of AFP type III proteins.

Purification, crystal structure determination and functional characterization of type III antifreeze proteins from the European eelpout Zoarces viviparus.,Wilkens C, Poulsen JC, Ramlov H, Leggio LL Cryobiology. 2014 Jul 12. pii: S0011-2240(14)00133-3. doi:, 10.1016/j.cryobiol.2014.07.003. PMID:25025819<ref>PMID:25025819</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ur4" style="background-color:#fffaf0;"></div>

==See Also==
*[[Antifreeze protein 3D structures|Antifreeze protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Zoarces viviparus]]
[[Category: Lo Leggio L]]
[[Category: Poulsen J-CN]]
[[Category: Ramloev H]]
[[Category: Wilkens C]]