View source for 4uvq


==PatG Domain of Unknown Function==
<StructureSection load='4uvq' size='340' side='right'caption='[[4uvq]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uvq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochloron_sp. Prochloron sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UVQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.724&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvq OCA], [https://pdbe.org/4uvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uvq RCSB], [https://www.ebi.ac.uk/pdbsum/4uvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uvq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q52QJ1_PRODI Q52QJ1_PRODI] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Patellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed mechanistic understanding of the biosynthetic pathway would enable the construction of a biotechnological `toolkit' to make novel analogues of patellamides that are not found in nature. All but two of the protein domains involved in patellamide biosynthesis have been characterized. The two domains of unknown function (DUFs) are homologous to each other and are found at the C-termini of the multi-domain proteins PatA and PatG. The domain sequence is found in all cyanobactin-biosynthetic pathways characterized to date, implying a functional role in cyanobactin biosynthesis. Here, the crystal structure of the PatG DUF domain is reported and its binding interactions with plausible substrates are investigated.

The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster.,Mann G, Koehnke J, Bent AF, Graham R, Houssen W, Jaspars M, Schwarz-Linek U, Naismith JH Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1597-603. doi:, 10.1107/S2053230X1402425X. Epub 2014 Nov 14. PMID:25484206<ref>PMID:25484206</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4uvq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Prochloron sp]]
[[Category: Bent AF]]
[[Category: Graham R]]
[[Category: Koehnke J]]
[[Category: Mann G]]
[[Category: Naismith JH]]
[[Category: Schwarz-Linek U]]