View source for 4uwl


==Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors==
<StructureSection load='4uwl' size='340' side='right'caption='[[4uwl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UWL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7A5:(8S)-2-[(3R)-3-METHYLMORPHOLIN-4-YL]-9-(3-METHYL-2-OXOBUTYL)-8-(TRIFLUOROMETHYL)-6,7,8,9-TETRAHYDRO-4H-PYRIMIDO[1,2-A]PYRIMIDIN-4-ONE'>7A5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uwl OCA], [https://pdbe.org/4uwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uwl RCSB], [https://www.ebi.ac.uk/pdbsum/4uwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uwl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> 

==See Also==
*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abecassis PY]]
[[Category: Arigon J]]
[[Category: Barriere C]]
[[Category: Benard T]]
[[Category: Bertin L]]
[[Category: Bertrand T]]
[[Category: Bretin F]]
[[Category: Brollo M]]
[[Category: Caron A]]
[[Category: Castell C]]
[[Category: Clement J]]
[[Category: Combet R]]
[[Category: Delbarre L]]
[[Category: Durand F]]
[[Category: Dureuil C]]
[[Category: El-Ahmad Y]]
[[Category: ElBatti S]]
[[Category: Fassy F]]
[[Category: Filoche-Romme B]]
[[Category: Garcia-Echeverria C]]
[[Category: Gay F]]
[[Category: Goulaouic H]]
[[Category: Labrosse JR]]
[[Category: Lefrancois D]]
[[Category: Leroy V]]
[[Category: Letallec JP]]
[[Category: Loyau V]]
[[Category: Marquette JP]]
[[Category: Mathieu M]]
[[Category: McCort G]]
[[Category: Michot N]]
[[Category: Pasquier B]]
[[Category: Perraut P]]
[[Category: Pilorge F]]
[[Category: Richepin P]]
[[Category: Ronan B]]
[[Category: Schio L]]
[[Category: Sonnefraud V]]