View source for 4uyi


==Crystal structure of the BTB domain of human SLX4 (BTBD12)==
<StructureSection load='4uyi' size='340' side='right'caption='[[4uyi]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UYI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [https://pdbe.org/4uyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [https://www.ebi.ac.uk/pdbsum/4uyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN] Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.<ref>PMID:19596235</ref> <ref>PMID:19596236</ref> <ref>PMID:19595721</ref> <ref>PMID:19595722</ref> 

==See Also==
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Bradley A]]
[[Category: Bullock A]]
[[Category: Burgess-Brown NA]]
[[Category: Chaikuad A]]
[[Category: Cooper CDO]]
[[Category: Edwards AM]]
[[Category: Fairhead M]]
[[Category: Filippakopoulos P]]
[[Category: Fitzpatrick F]]
[[Category: Hozjan V]]
[[Category: Kopec J]]
[[Category: Krojer T]]
[[Category: Marsden BD]]
[[Category: Nowak R]]
[[Category: Pike ACW]]
[[Category: Pinkas DM]]
[[Category: Roos AK]]
[[Category: Sanvitale CE]]
[[Category: Savitsky P]]
[[Category: Sorrell FJ]]
[[Category: Strain-Damerell C]]
[[Category: Tallant C]]
[[Category: Wang D]]
[[Category: Ying Z]]
[[Category: Von Delft F]]