View source for 4v38


==Apo-structure of alpha2,3-sialyltransferase variant 1 from Pasteurella dagmatis==
<StructureSection load='4v38' size='340' side='right'caption='[[4v38]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4v38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pasteurella_dagmatis Pasteurella dagmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V38 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v38 OCA], [https://pdbe.org/4v38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v38 RCSB], [https://www.ebi.ac.uk/pdbsum/4v38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v38 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/K9UUI6_9PAST K9UUI6_9PAST] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structure-guided active-site redesign of a family GT-80 beta-D-galactoside sialyltransferase (from Pasteurella dagmatis) to change enzyme regioselectivity from alpha-2,3 in the wild type to alpha-2,6 in a P7H-M117A double mutant is reported. Biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering.

Complete switch from alpha-2,3- to alpha-2,6-regioselectivity in Pasteurella dagmatis beta-D-galactoside sialyltransferase by active-site redesign.,Schmolzer K, Czabany T, Luley-Goedl C, Pavkov-Keller T, Ribitsch D, Schwab H, Gruber K, Weber H, Nidetzky B Chem Commun (Camb). 2015 Feb 21;51(15):3083-6. doi: 10.1039/c4cc09772f. PMID:25619424<ref>PMID:25619424</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4v38" style="background-color:#fffaf0;"></div>

==See Also==
*[[Sialyltransferase 3D structures|Sialyltransferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pasteurella dagmatis]]
[[Category: Czabany T]]
[[Category: Gruber K]]
[[Category: Luley-Goedl C]]
[[Category: Nidetzky B]]
[[Category: Pavkov-Keller T]]
[[Category: Ribitsch D]]
[[Category: Schmoelzer K]]
[[Category: Schwab H]]