View source for 4wd3


==Crystal structure of an L-amino acid ligase RizA==
<StructureSection load='4wd3' size='340' side='right'caption='[[4wd3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis Bacillus subtilis subsp. subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WD3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wd3 OCA], [https://pdbe.org/4wd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wd3 RCSB], [https://www.ebi.ac.uk/pdbsum/4wd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wd3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RIZA_BACIU RIZA_BACIU] Catalyzes the synthesis of Arg-Xaa dipeptides in an ATP-dependent manner. Has strict specificity toward arginine as the N-terminal substrate.<ref>PMID:19352016</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RizA is an L-amino-acid ligase from Bacillus subtilis that participates in the biosynthesis of rhizocticin, an oligopeptide antibiotic. The substrate-free form of RizA has been crystallized and the structure was solved at 2.8 A resolution. The amino-acid-binding site appears to be capable of accommodating multiple amino acids, consistent with previous biochemical studies.

Structure of RizA, an L-amino-acid ligase from Bacillus subtilis.,Kagawa W, Arai T, Ishikura S, Kino K, Kurumizaka H Acta Crystallogr F Struct Biol Commun. 2015 Sep;71(Pt 9):1125-30. doi:, 10.1107/S2053230X15012698. Epub 2015 Aug 25. PMID:26323296<ref>PMID:26323296</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4wd3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis]]
[[Category: Large Structures]]
[[Category: Arai T]]
[[Category: Kagawa W]]
[[Category: Kino K]]
[[Category: Kurumizaka H]]