View source for 4wja


==Crystal Structure of PAXX==
<StructureSection load='4wja' size='340' side='right'caption='[[4wja]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WJA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wja OCA], [https://pdbe.org/4wja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wja RCSB], [https://www.ebi.ac.uk/pdbsum/4wja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wja ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAXX_HUMAN PAXX_HUMAN] Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:25574025, PubMed:25670504, PubMed:25941166, PubMed:27705800). May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:25574025, PubMed:25670504, PubMed:25941166). Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (PubMed:27703001). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:30250067, PubMed:25670504). Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27705800). Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism (PubMed:29144403).<ref>PMID:25574025</ref> <ref>PMID:25670504</ref> <ref>PMID:25941166</ref> <ref>PMID:27703001</ref> <ref>PMID:27705800</ref> <ref>PMID:29144403</ref> <ref>PMID:30250067</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dong C]]
[[Category: Feng F]]
[[Category: Gao G]]
[[Category: Guo R]]
[[Category: Hou M]]
[[Category: Huo W]]
[[Category: Ji J]]
[[Category: Lan L]]
[[Category: Li W]]
[[Category: Liang H]]
[[Category: Ning S]]
[[Category: Wang Q]]
[[Category: Wei L]]
[[Category: Xing M]]
[[Category: Xu D]]
[[Category: Yan Z]]
[[Category: Yang M]]