View source for 4woq


==Crystal Structures of CdNal from Clostridium difficile in complex with ketobutyric==
<StructureSection load='4woq' size='340' side='right'caption='[[4woq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4woq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile_NAP08 Clostridioides difficile NAP08]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WOQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2KT:2-KETOBUTYRIC+ACID'>2KT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4woq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4woq OCA], [https://pdbe.org/4woq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4woq RCSB], [https://www.ebi.ac.uk/pdbsum/4woq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4woq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D5Q364_CLODI D5Q364_CLODI] Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.[HAMAP-Rule:MF_01237]

==See Also==
*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
__TOC__
</StructureSection>
[[Category: Clostridioides difficile NAP08]]
[[Category: Large Structures]]
[[Category: Chen X]]
[[Category: Cui YF]]
[[Category: Guo RT]]
[[Category: Liu WD]]
[[Category: Wu QQ]]
[[Category: Zhu DM]]