View source for 4wp2


==Chaetomium Mex67 UBA domain==
<StructureSection load='4wp2' size='340' side='right'caption='[[4wp2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wp2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WP2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wp2 OCA], [https://pdbe.org/4wp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wp2 RCSB], [https://www.ebi.ac.uk/pdbsum/4wp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wp2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G0SET4_CHATD G0SET4_CHATD] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Members of the Mex67-Mtr2/NXF-NXT1 family are the principal mediators of the nuclear export of mRNA. Mex67/NXF1 has a modular structure based on four domains (RRM, LRR, NTF2-like and UBA) that are thought to be present across species, although the level of sequence conservation between organisms, especially in lower eukaryotes, is low. Here, the crystal structures of these domains from the thermophilic fungus Chaetomium thermophilum are presented together with small-angle X-ray scattering (SAXS) and in vitro RNA-binding data that indicate that, not withstanding the limited sequence conservation between different NXF family members, the molecules retain similar structural and RNA-binding properties. Moreover, the resolution of crystal structures obtained with the C. thermophilum domains was often higher than that obtained previously and, when combined with solution and biochemical studies, provided insight into the structural organization, self-association and RNA-binding properties of Mex67-Mtr2 that facilitate mRNA nuclear export.

Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.,Aibara S, Valkov E, Lamers MH, Dimitrova L, Hurt E, Stewart M Acta Crystallogr F Struct Biol Commun. 2015 Jul;71(Pt 7):876-88. doi:, 10.1107/S2053230X15008766. Epub 2015 Jun 27. PMID:26144233<ref>PMID:26144233</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4wp2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
[[Category: Large Structures]]
[[Category: Aibara S]]
[[Category: Stewart M]]