View source for 4wqn


==Crystal structure of N6-methyladenosine RNA reader YTHDF2==
<StructureSection load='4wqn' size='340' side='right'caption='[[4wqn]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wqn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WQN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.121&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wqn OCA], [https://pdbe.org/4wqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wqn RCSB], [https://www.ebi.ac.uk/pdbsum/4wqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wqn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: He C]]
[[Category: Li J]]
[[Category: Roundtree IA]]
[[Category: Sun C]]
[[Category: Tian Y]]
[[Category: Wang L]]
[[Category: Wang P]]
[[Category: Wang X]]
[[Category: Xu Y]]
[[Category: Zhu T]]