View source for 4wzx


==ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins==
<StructureSection load='4wzx' size='340' side='right'caption='[[4wzx]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wzx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WZX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3859&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wzx OCA], [https://pdbe.org/4wzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wzx RCSB], [https://www.ebi.ac.uk/pdbsum/4wzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wzx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ULK3_HUMAN ULK3_HUMAN] Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.<ref>PMID:19279323</ref> <ref>PMID:19878745</ref> <ref>PMID:20643644</ref> 

==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Agromayor M]]
[[Category: Alam SL]]
[[Category: Caballe A]]
[[Category: Carlton JG]]
[[Category: Kloc M]]
[[Category: Labrador L]]
[[Category: Martin-Serrano J]]
[[Category: Skalicky JJ]]
[[Category: Sundquist WI]]
[[Category: Wenzel DM]]