View source for 4x08


==Structure of H128N/ECP mutant in complex with sulphate anions at 1.34 Angstroms.==
<StructureSection load='4x08' size='340' side='right'caption='[[4x08]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4x08]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X08 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x08 OCA], [https://pdbe.org/4x08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x08 RCSB], [https://www.ebi.ac.uk/pdbsum/4x08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x08 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ECP_HUMAN ECP_HUMAN] Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.<ref>PMID:2501794</ref> <ref>PMID:19450231</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Blanco JA]]
[[Category: Boix E]]
[[Category: Garcia JM]]
[[Category: Moussauoi M]]
[[Category: Salazar VA]]
[[Category: Sanchez D]]