View source for 4xgq


==Crystal structure of addiction module from Mycobacterial species==
<StructureSection load='4xgq' size='340' side='right'caption='[[4xgq]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4xgq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XGQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgq OCA], [https://pdbe.org/4xgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xgq RCSB], [https://www.ebi.ac.uk/pdbsum/4xgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xgq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VPC30_MYCTU VPC30_MYCTU] Toxic component of a type II toxin-antitoxin (TA) module. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB30.[HAMAP-Rule:MF_00265]<ref>PMID:20011113</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Lee B-J]]
[[Category: Lee I-G]]
[[Category: Lee SJ]]