View source for 4xtk


==Structure of TM1797, a CAS1 protein from Thermotoga maritima==
<StructureSection load='4xtk' size='340' side='right'caption='[[4xtk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4xtk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3lfx 3lfx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XTK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xtk OCA], [https://pdbe.org/4xtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xtk RCSB], [https://www.ebi.ac.uk/pdbsum/4xtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xtk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAS1_THEMA CAS1_THEMA] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).

==See Also==
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima MSB8]]
[[Category: Beloglazova N]]
[[Category: Chang C]]
[[Category: Edwards A]]
[[Category: Joachimiak A]]
[[Category: Petit P]]
[[Category: Savchenko A]]
[[Category: Skarina T]]