View source for 4ycz


==Y-COMPLEX HUB (NUP85-NUP120-NUP145C-SEC13 COMPLEX) FROM M. THERMOPHILA (A.K.A. T. HETEROTHALLICA)==
<StructureSection load='4ycz' size='340' side='right'caption='[[4ycz]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ycz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermothelomyces_thermophilus_ATCC_42464 Thermothelomyces thermophilus ATCC 42464]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YCZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ycz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ycz OCA], [https://pdbe.org/4ycz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ycz RCSB], [https://www.ebi.ac.uk/pdbsum/4ycz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ycz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G2QES5_THET4 G2QES5_THET4] [https://www.uniprot.org/uniprot/G2QEZ2_THET4 G2QEZ2_THET4] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The nuclear pore complex (NPC) is the principal gateway for transport into and out of the nucleus. Selectivity is achieved through the hydrogel-like core of the NPC. The structural integrity of the NPC depends on ~15 architectural proteins, which are organized in distinct subcomplexes to form the &gt;40-MDa ring-like structure. Here we present the 4.1-A crystal structure of a heterotetrameric core element ('hub') of the Y complex, the essential NPC building block, from Myceliophthora thermophila. Using the hub structure together with known Y-complex fragments, we built the entire ~0.5-MDa Y complex. Our data reveal that the conserved core of the Y complex has six rather than seven members. Evolutionarily distant Y-complex assemblies share a conserved core that is very similar in shape and dimension, thus suggesting that there are closely related architectural codes for constructing the NPC in all eukaryotes.

Atomic structure of the Y complex of the nuclear pore.,Kelley K, Knockenhauer KE, Kabachinski G, Schwartz TU Nat Struct Mol Biol. 2015 Mar 30. doi: 10.1038/nsmb.2998. PMID:25822992<ref>PMID:25822992</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ycz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermothelomyces thermophilus ATCC 42464]]
[[Category: Kelley K]]
[[Category: Knockenhauer KE]]
[[Category: Schwartz TU]]