View source for 4yxq


==PksG, a HMG-CoA Synthase from Bacillus subtilis==
<StructureSection load='4yxq' size='340' side='right'caption='[[4yxq]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4yxq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxq OCA], [https://pdbe.org/4yxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxq RCSB], [https://www.ebi.ac.uk/pdbsum/4yxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PKSG_BACSU PKSG_BACSU] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac-AcpK) and a beta-ketothioester polyketide intermediate linked to one of the consecutive thiolation domains of PksL.<ref>PMID:16757561</ref> <ref>PMID:17234808</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Nair AV]]
[[Category: Race PR]]
[[Category: Till M]]