View source for 4yxv


==PksG, a HMG-CoA Synthase from Bacillus subtilus==
<StructureSection load='4yxv' size='340' side='right'caption='[[4yxv]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4yxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxv OCA], [https://pdbe.org/4yxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxv RCSB], [https://www.ebi.ac.uk/pdbsum/4yxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PKSG_BACSU PKSG_BACSU] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac-AcpK) and a beta-ketothioester polyketide intermediate linked to one of the consecutive thiolation domains of PksL.<ref>PMID:16757561</ref> <ref>PMID:17234808</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Nair AV]]
[[Category: Race PR]]
[[Category: Robson A]]
[[Category: Till M]]