View source for 4zmi


==Crystal structure of the Helical domain of S. pombe Taz1==
<StructureSection load='4zmi' size='340' side='right'caption='[[4zmi]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4zmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZMI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmi OCA], [https://pdbe.org/4zmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zmi RCSB], [https://www.ebi.ac.uk/pdbsum/4zmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TAZ1_SCHPO TAZ1_SCHPO] Regulates telomere length and function. Required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation. It may be involved in the interactions between chromosomes and spindle proteins, disruption of these interactions would lead to defective meiosis.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Deng W]]
[[Category: Lei M]]
[[Category: Wang F]]
[[Category: Wu J]]