View source for 4zqh


==Crystal structure of DOX-P Reductoisomerase in complex with NADPH, fosmidomycin and magnesium==
<StructureSection load='4zqh' size='340' side='right'caption='[[4zqh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4zqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moraxella_catarrhalis Moraxella catarrhalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZQH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOM:3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC+ACID'>FOM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqh OCA], [https://pdbe.org/4zqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zqh RCSB], [https://www.ebi.ac.uk/pdbsum/4zqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D5VAW2_MORCB D5VAW2_MORCB] Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]

==See Also==
*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Moraxella catarrhalis]]
[[Category: Birkinshaw RW]]
[[Category: Brady RL]]