View source for 5ail


==Human PARP9 2nd macrodomain==
<StructureSection load='5ail' size='340' side='right'caption='[[5ail]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ail]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AIL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ail FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ail OCA], [https://pdbe.org/5ail PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ail RCSB], [https://www.ebi.ac.uk/pdbsum/5ail PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ail ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PARP9_HUMAN PARP9_HUMAN] Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors.
== Function ==
[https://www.uniprot.org/uniprot/PARP9_HUMAN PARP9_HUMAN] In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.<ref>PMID:16809771</ref> <ref>PMID:23230272</ref> 

==See Also==
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: Elkins JM]]
[[Category: Knapp S]]
[[Category: Shrestha L]]
[[Category: Sieg C]]
[[Category: Sorrell F]]
[[Category: Talon R]]
[[Category: Williams E]]
[[Category: Von Delft F]]