View source for 5ame


==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==
<StructureSection load='5ame' size='340' side='right'caption='[[5ame]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AME FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.578&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ame OCA], [https://pdbe.org/5ame PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ame RCSB], [https://www.ebi.ac.uk/pdbsum/5ame PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ame ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> 

==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Bowkett D]]
[[Category: Bradley A]]
[[Category: Brandao-Neto J]]
[[Category: Brennan P]]
[[Category: Burgess-Brown N]]
[[Category: Collins P]]
[[Category: Cox O]]
[[Category: Douangamath A]]
[[Category: Edwards E]]
[[Category: Fairhead M]]
[[Category: Krojer T]]
[[Category: Ng JT]]
[[Category: Pearce NM]]
[[Category: Strain-Damerell C]]
[[Category: Talon R]]
[[Category: Wright N]]
[[Category: Von Delft F]]