View source for 5axc


==Crystal structure of mouse SAHH complexed with 3'-keto aristeromycin==
<StructureSection load='5axc' size='340' side='right'caption='[[5axc]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5axc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AXC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARJ:(2S,3R,5R)-3-(6-AMINO-9H-PURIN-9-YL)-2-HYDROXY-5-(HYDROXYMETHYL)CYCLOPENTANONE'>ARJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5axc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5axc OCA], [https://pdbe.org/5axc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5axc RCSB], [https://www.ebi.ac.uk/pdbsum/5axc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5axc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAHH_MOUSE SAHH_MOUSE] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ishihara M]]
[[Category: Kusakabe Y]]
[[Category: Tanaka N]]