View source for 5axd


==Crystal structure of mouse SAHH complexed with ribavirin==
<StructureSection load='5axd' size='340' side='right'caption='[[5axd]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5axd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AXD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=RBV:1-(BETA-D-RIBOFURANOSYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE'>RBV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5axd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5axd OCA], [https://pdbe.org/5axd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5axd RCSB], [https://www.ebi.ac.uk/pdbsum/5axd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5axd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAHH_MOUSE SAHH_MOUSE] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ishihara M]]
[[Category: Kusakabe Y]]
[[Category: Tanaka N]]