View source for 5axs


==Crystal structure of CdCat-Fn==
<StructureSection load='5axs' size='340' side='right'caption='[[5axs]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5axs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AXS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4LF:N-[2-[2,5-BIS(OXIDANYLIDENE)PYRROL-1-YL]ETHYL]-2,3-BIS(OXIDANYL)BENZAMIDE'>4LF</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5axs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5axs OCA], [https://pdbe.org/5axs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5axs RCSB], [https://www.ebi.ac.uk/pdbsum/5axs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5axs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A set of three catecholamide ligands mimicking the structure of enterobactin was constructed on ferritin, where the 3-fold symmetric arrangement of the monomer subunits served as a foundation to form a coordination space. Similar to enterobactin, the ligands showed strong affinity for the ferric ion and formed a tris-catechoyl complex. Crystallography revealed that the complex was embedded in the entrance of the 3-fold axis channel.

Construction of an enterobactin analogue with symmetrically arranged monomer subunits of ferritin.,Nakajima H, Kondo M, Nakane T, Abe S, Nakao T, Watanabe Y, Ueno T Chem Commun (Camb). 2015 Dec 4;51(93):16609-12. doi: 10.1039/c5cc06904a. Epub, 2015 Sep 25. PMID:26404005<ref>PMID:26404005</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5axs" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ferritin 3D structures|Ferritin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Equus caballus]]
[[Category: Large Structures]]
[[Category: Abe S]]
[[Category: Kondo M]]
[[Category: Nakajima H]]
[[Category: Nakane T]]
[[Category: Nakao T]]
[[Category: Ueno T]]
[[Category: Watanabe Y]]