View source for 5bqi


==Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain==
<StructureSection load='5bqi' size='340' side='right'caption='[[5bqi]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5bqi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BQI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KA:(2-HYDROXYETHOXY)ACETALDEHYDE'>1KA</scene>, <scene name='pdbligand=4UL:2-(DIFLUOROMETHYL)-5-{[(2-METHYLPROPANOYL)AMINO]METHYL}-N-{5-METHYL-4-[4-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOL-2-YL}PYRIDINE-3-CARBOXAMIDE'>4UL</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqi OCA], [https://pdbe.org/5bqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bqi RCSB], [https://www.ebi.ac.uk/pdbsum/5bqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref> 

==See Also==
*[[Prostaglandin E synthase|Prostaglandin E synthase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Antonysamy S]]
[[Category: Fisher MJ]]
[[Category: Kuklish SL]]
[[Category: Luz JG]]
[[Category: Schiffler MA]]