View source for 5buh


==Influenza PB2 bound to a hydroxymethyl azaindole inhibitor==
<StructureSection load='5buh' size='340' side='right'caption='[[5buh]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5buh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Beijing/39/1975(H3N2)) Influenza A virus (A/Beijing/39/1975(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BUH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4V7:N-[(1R,3S)-3-({5-FLUORO-2-[5-FLUORO-2-(HYDROXYMETHYL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]PYRIMIDIN-4-YL}AMINO)CYCLOHEXYL]PYRROLIDINE-1-CARBOXAMIDE'>4V7</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5buh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5buh OCA], [https://pdbe.org/5buh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5buh RCSB], [https://www.ebi.ac.uk/pdbsum/5buh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5buh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PB2_I75A0 PB2_I75A0] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]

==See Also==
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Jacobs MD]]