View source for 5c37


==Structure of the beta-ketoacyl reductase domain of human fatty acid synthase bound to a spiro-imidazolone inhibitor==
<StructureSection load='5c37' size='340' side='right'caption='[[5c37]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5c37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C37 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4XN:6-{[(3R)-1-(CYCLOPROPYLCARBONYL)PYRROLIDIN-3-YL]METHYL}-5-[4-(1-METHYL-1H-INDAZOL-5-YL)PHENYL]-4,6-DIAZASPIRO[2.4]HEPT-4-EN-7-ONE'>4XN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c37 OCA], [https://pdbe.org/5c37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c37 RCSB], [https://www.ebi.ac.uk/pdbsum/5c37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c37 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

==See Also==
*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Grasberger B]]
[[Category: Milligan CM]]
[[Category: Schubert C]]
[[Category: Vo K]]