View source for 5c59


==Crystal structure of the periplasmic region of MacB from E. coli==
<StructureSection load='5c59' size='340' side='right'caption='[[5c59]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5c59]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_536 Escherichia coli 536]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C59 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c59 OCA], [https://pdbe.org/5c59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c59 RCSB], [https://www.ebi.ac.uk/pdbsum/5c59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c59 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MACB_ECOL5 MACB_ECOL5] Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
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</StructureSection>
[[Category: Escherichia coli 536]]
[[Category: Large Structures]]
[[Category: Ha NC]]
[[Category: Kim JS]]