View source for 5cqr


==Dimerization of Elp1 is essential for Elongator complex assembly==
<StructureSection load='5cqr' size='340' side='right'caption='[[5cqr]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cqr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CQR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.015&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cqr OCA], [https://pdbe.org/5cqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cqr RCSB], [https://www.ebi.ac.uk/pdbsum/5cqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cqr ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ELP1_HUMAN ELP1_HUMAN] Familial dysautonomia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ELP1_HUMAN ELP1_HUMAN] May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).  Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).[UniProtKB:Q7TT37]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Diao W]]
[[Category: Li F]]
[[Category: Lin Z]]
[[Category: Long J]]
[[Category: Shen Y]]
[[Category: Xu H]]