View source for 5ctq


==Crystal structure of human SART3/TIP110 half-a TPR (HAT) domain==
<StructureSection load='5ctq' size='340' side='right'caption='[[5ctq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ctq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctq OCA], [https://pdbe.org/5ctq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctq RCSB], [https://www.ebi.ac.uk/pdbsum/5ctq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctq ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SART3_HUMAN SART3_HUMAN] Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:[https://omim.org/entry/175900 175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.<ref>PMID:15840095</ref> 
== Function ==
[https://www.uniprot.org/uniprot/SART3_HUMAN SART3_HUMAN] Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.<ref>PMID:11959860</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kim EE]]
[[Category: Park JK]]