View source for 5cva


==Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a1a2a1 of type I collagen==
<StructureSection load='5cva' size='340' side='right'caption='[[5cva]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cva]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CVA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.098&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cva OCA], [https://pdbe.org/5cva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cva RCSB], [https://www.ebi.ac.uk/pdbsum/5cva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cva ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CO9A1_HUMAN CO9A1_HUMAN] Defects in COL9A1 are the cause of multiple epiphyseal dysplasia type 6 (EDM6) [MIM:[https://omim.org/entry/614135 614135]. A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal.<ref>PMID:11565064</ref>   Defects in COL9A1 are the cause of Stickler syndrome type 4 (STL4) [MIM:[https://omim.org/entry/614134 614134]. An autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable.<ref>PMID:16909383</ref> [https://www.uniprot.org/uniprot/CO1A2_HUMAN CO1A2_HUMAN] Osteogenesis imperfecta type 4;Osteogenesis imperfecta type 1;Ehlers-Danlos syndrome type 7B;Ehlers-Danlos/osteogenesis imperfecta syndrome;Osteogenesis imperfecta type 2;Ehlers-Danlos syndrome, cardiac valvular type;High bone mass osteogenesis imperfecta;Osteogenesis imperfecta type 3. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7;8)(p22;q13) with PLAG1.
== Function ==
[https://www.uniprot.org/uniprot/CO9A1_HUMAN CO9A1_HUMAN] Structural component of hyaline cartilage and vitreous of the eye.[https://www.uniprot.org/uniprot/CO1A2_HUMAN CO1A2_HUMAN] Type I collagen is a member of group I collagen (fibrillar forming collagen).
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== Publication Abstract from PubMed ==
Collagen plays a fundamental role in all known metazoans. In collagens three polypeptides form a unique triple-helical structure with a one-residue stagger to fit every third glycine residue in the inner core without disturbing the poly-proline type II helical conformation of each chain. There are homo- and hetero-trimeric types of collagen consisting of one, two or three distinct chains. Thus there must be mechanisms that control composition and stagger during collagen folding. Here, we uncover the structural basis for both chain selection and stagger formation of a collagen molecule. Three distinct chains (alpha1, alpha2 and alpha3) of the non-collagenous domain 2 (NC2) of type IX collagen are assembled to guide triple-helical sequences in the leading, middle and trailing positions. This unique domain opens the door for generating any fragment of collagen in its native composition and stagger.

Structural insight for chain selection and stagger control in collagen.,Boudko SP, Bachinger HP Sci Rep. 2016 Nov 29;6:37831. doi: 10.1038/srep37831. PMID:27897211<ref>PMID:27897211</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 5cva" style="background-color:#fffaf0;"></div>

==See Also==
*[[Collagen 3D structures|Collagen 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bachinger HP]]
[[Category: Boudko SP]]